I’ve read that the degradation products of Indole-3-Carbinol are harmful so Diindolylmethane (DIM) should be substituted in its place. Are you aware of this?
I’m aware of this claim, but for this to be true, eating broccoli should also be harmful. While it is true that I3C forms numerous other products in the stomach acid environment, it is a bit of a stretch to assume that DIM is the major benefit provider. Scientists have identified at least 23 different components formed upon the ingestion of I3C. Only a few have even been examined for biological effects. While DIM is the major degradation component at 10%, it is entirely feasible that other minor degradation products exhibit a greater biological benefit when compared on a wt/wt basis. Several published studies have already demonstrated that the benefits associated with ingesting I3C cannot be attributed solely to DIM. The greatest benefit was in fact realized with a mixture of I3C degradation products.
We must be careful to avoid the same mistake that scientists made with singling out vitamin C (L ascorbic acid). We now know that vitamin C exists in numerous forms, each one providing a unique and important function in the body. Scientists focused on I3C and DIM because of the apparent benefits associated with cruciferous vegetables. However, they initially overlooked the primary dietary indole (ascorbigen) associated with these vegetables just by the isolation method they utilized. The degradation products associated with I3C are inherent in the consumption of the cruciferous vegetables we revere. Who knows what beneficial synergies future research will uncover?