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What is the difference between Indole-3-Carbinol (I3C) and Diindolylmethane (DIM)?


In the stomach, I3C forms numerous compounds of which only a handful have been characterized. Reportedly, an oral dose of I3C produces at least 24 distinct indole degradation products in vivo. It is possible that some of the minor degradation products also have significant physiological effects not yet identified.

DIM is the primary degradation product of I3C, comprising 10% of the species formed upon ingestion. DIM is also the most prevalent degradation product isolated from liver tissue following ingestion of I3C. A few studies indicate that DIM is more effective than I3C at modulating certain estrogen metabolites in a desirable fashion. In regards to this particular effect, DIM is possibly 10 times more cost effective than I3C. DIM is slightly more heat stable than I3C but rapidly degrades in the presence of light.
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