Dietary Benefit
Brox-25 contains 25% of mixed dietary indoles. Dietary indoles support the body’s ability to eliminate toxins from the liver [1], optimize the body’s natural metabolism of hormones, and promote good estrogen (2-Hydroxy-estrone) [2,3]. Dietary indoles are important factors in promoting women’s health [4-9].

400-1600 mg daily

Product Overview
Nutritional supplements containing Dietary Indoles have been marketed since 1990. In cruciferous vegetables such as broccoli, cauliflower, cabbage, and brussels sprouts, a series of compounds react when the vegetable cell walls are broken through chopping, chewing, or juicing [10]. A wide variety of Dietary Indoles are produced in this way*. Dietary Indoles have significant physiological activity [11].
Designed Nutritional Products offers the only broccoli powder product standardized to 25% Dietary Indoles. Brox-25 includes Ascorbigen, Diindolyl-methane (DIM), and Indole-3-Carbinol (I3C). A few capsules will deliver the same Dietary Indole benefit as several pounds of cruciferous vegetables.

Most Dietary Indoles are heat and/or light sensitive. The degradation products of Dietary Indoles are considered beneficial and are the same as those formed in the stomach upon ingestion.


Dietary Indole blend. No CAS Registry Number available.

Regulatory Status
Dietary Indoles are dietary supplements under provisions of US Dietary Supplement Health and Education Act of 1994 (DSHEA).

Amounts in excess of recommended dosages may cause diarrhea.

1. McDanell, R., ETL, 1987 Food and Chemical Toxicology
25: 363-368.
2. Michnovicz, J. J.; Bradlow, H. L. 1991 Nutr. Cancer 16: 59-66. 3. Michnovicz, J. J.; Bradlow, H. L. 1990 Natl. Can. Inst. 82: 947-949
4. Michnovicz J.J., Bradlow H.L., 1993 Food Phytochemicals I: Fruits and Vegetables 282-293.
5. Sepkovic, D. et al. 1994 Steroids 59: 318-323.
6. Ge, X., Yannai S., Rennert G., Gruener N., Gares F.A. 1996
Biochem Diophys Res Commun 28:153-165.
7. Bell, M.C., ETL, 2000, Gynecologic Oncology 78: 123-129.
8. Newfield, L., ETL, 1993, Anticancer Research 13: 337-342.
9. Michnovicz J.J., Bradlow H.L., 1989 Proc. Royal Soc. Endinburgh 12: 1571-157.
10. Zeligs, M.A., 1998, Journal of Medicinal Food, 1:2, 67-82
11. Loub W.E., Wattenberg L.W., Davis D.W., 1975 J. Nat. Can. Inst. 54: 985-988.
12. Andrus, G.M., Arffman, K., 1999 United States Patent. 5895787, April 20.

* While these compounds occur naturally, they exist in extremely low quantities. All commercial sources are synthetic.

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