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Sleep Support · Single Ingredient · Product No. 8019

Melatonin

N-Acetyl-5-methoxytryptamine · CAS 73-31-4

High-purity bulk Melatonin powder, 99.8% HPLC purity. Not from animal origin. Supports normal sleep cycle regulation and healthy circadian rhythm.* Heat and light stable with excellent long-term stability — samples stored under normal conditions show virtually no degradation after 6 years. Warehoused and tested in the USA. COA provided with every order.

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CAS Number
73-31-4
Molecular Weight
232.28 g/mol
Assay (HPLC area %)
>99.8%
Assay (HPLC std ref)
>98.5%
Origin
China (not animal)
Regulatory Status
DSHEA Compliant
Ordering Information
Melatonin — Bulk Powder
FormWhite powder
Purity>99.8% HPLC
Minimum Order1 kg
Shelf Life2 years
StorageHeat & light stable
PackagingCardboard box + plastic bags
OriginChina (not animal origin)
PricingRequest a quote

COA provided with every order · SDS available on request

Full Technical Specifications

Certificate of Analysis — Specification Sheet

Identification & Physical Properties
Product Number8019
CAS Registry Number73-31-4
SynonymsN-Acetyl-5-methoxytryptamine, Regulin
Molecular FormulaC₁₃H₁₆N₂O₂
Molecular Weight232.28 g/mol
AppearanceWhite powder
IdentificationInfrared spectrum
SolubilityClear solution in methanol
Melting Point117.0–120.0°C
Loss on Drying< 0.5%
Water Content (K.F.)< 0.2%
OriginChina (not animal origin)
Assay
HPLC — Standard Reference> 98.5%
HPLC — Area %> 99.8%
Heavy Metals
Arsenic< 1 ppm
Cadmium< 1 ppm
Lead< 1 ppm
Mercury< 1 ppm
Stability
Shelf Life2 years
Heat StabilityStable
Light StabilityStable
Long-term StabilityNo significant degradation at 6 years
StorageAmbient, normal conditions
Ordering
Minimum Order1 kg
PackagingCardboard box + plastic bags
Manufactured / TestedUSA warehoused & tested
Formulation Benefits

Why formulators choose Designed Nutritional Melatonin

Melatonin is a well-established dietary supplement ingredient with a strong published research base spanning decades. First isolated in 1958, it supports normal sleep cycle regulation and healthy circadian rhythm.* Designed Nutritional's bulk Melatonin is sourced from China — not from animal origin — warehoused and tested in the USA, with one of the most stable profiles of any ingredient in our portfolio.

Oral doses of Melatonin show peak plasma levels approximately 60 minutes after ingestion. Light-dependent circadian rhythms are influenced by Melatonin in mammals, with research spanning sleep cycle regulation and healthy biological clock function.* [Ref. 4, 5, 6]
Suggested Dosage Range
1–5 mg, 30 min before bedtime
Take 30 minutes before desired sleep time. Do not take prior to driving or operating machinery.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Sleep Cycle Support*

Melatonin supports normal sleep cycle regulation and healthy circadian rhythm.* Published research has examined the role of Melatonin in supporting natural sleep onset at desired times, including for individuals experiencing occasional sleeplessness associated with shift work or jet lag.*

Ref. [5] Arendt, 1995 · Ref. [6] Reiter & Robinson, 1995
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Circadian Rhythm Regulation*

Melatonin plays a key role in regulating the body's internal clock. Published research has examined how Melatonin supports normal biological clock function, with peak plasma levels occurring approximately 60 minutes after oral ingestion.* Light-dependent rhythms in mammals are well-documented in the literature.*

Ref. [4] Axelrod, 1974 · Ref. [5] Arendt, 1995
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99.8% HPLC Purity

Designed Nutritional's Melatonin is tested to >99.8% purity by HPLC area % and >98.5% by standard reference method. Heavy metals (arsenic, cadmium, lead, mercury) all confirmed below 1 ppm. Identity confirmed by infrared spectrum. Full COA with every order.

Product Specification — Designed Nutritional No. 8019
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Not From Animal Origin

Designed Nutritional's Melatonin is not derived from animal pineal glands. While Melatonin was first isolated from bovine pineal glands in 1958, our bulk Melatonin is synthetically produced — making it suitable for vegetarian, vegan, and halal formulations without compromise on purity.

Product Specification — Designed Nutritional No. 8019
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Exceptional Stability Profile

Melatonin is both heat and light stable — an unusual combination that simplifies formulation and storage. Samples stored under normal conditions show virtually no degradation after 6 years. 2-year formal shelf life under normal storage conditions. No special packaging or refrigeration required.

Stability Data — Designed Nutritional No. 8019
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Low MOQ — 1 kg

Minimum order of just 1 kg makes Melatonin accessible for initial formulation runs, sampling, and smaller production batches. Warehoused and tested in the USA at our Orem, Utah facility. Packaged in cardboard boxes with inner plastic bags. Full COA and SDS available.

Product Specification — Designed Nutritional No. 8019
Packaging & Ordering

Available packaging options

01

Standard Orders

Packaged in cardboard boxes with inner plastic bags. 1 kg minimum order makes it accessible for initial formulation runs and smaller production batches.

Cardboard box + plastic bags · MOQ 1 kg
02

Bulk Orders

For larger production runs. Contact us for bulk pricing and packaging options tailored to your volume and logistics requirements.

03

Samples

Samples available for qualified manufacturers. Send us a message with your formulation requirements and our team will get back to you promptly.

Classification & Regulatory
CAS Number73-31-4
ClassificationPineal hormone analog
Regulatory StatusDSHEA Compliant
Facility RegistrationFDA Registered
GMP Standard21 CFR Part 117
OriginChina
Animal originNo — synthetic
Warehoused & testedUSA (Orem, Utah)
Precautions & Warnings
Do not use if: pregnant or lactating, have autoimmune conditions, have depressive disorders, or are under 16 years of age.
Do not take prior to driving an automobile or operating machinery.
Long-term safety: Full toxicological studies on the effects of continuous use over periods of years have not been completed.
Timing: Take 30 minutes before desired sleep time. Do not take within 6 hours of when you need to be alert.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Scientific References

Published Research

[1] Lerner A.B. et al. J. Am. Chem. Soc. 80, 2587. 1958. — First isolation and identification of Melatonin from bovine pineal glands.
[2] Lerner A.B. et al. J. Org. Chem. Soc. 81, 6084. 1959.
[3] Szmuszkovicz. J. Org. Chem. 25, 857. 1960.
[4] Axelrod J. Science. 184: 1341–1348. 1974. — Research on Melatonin and biological clock regulation.
[5] Arendt J. Melatonin and the Mammalian Pineal Gland. Chapman and Hall, London. 1995. — Comprehensive reference on Melatonin physiology and circadian function.
[6] Reiter R.J. and Robinson Jo. MELATONIN: Your Body's Natural Wonder Drug. Bantam Books, New York. 1995.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References are published third-party research provided for informational purposes only.