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Hormone Balance · Bulk Ingredient · Product No. 8038

Indole-3-Carbinol (I3C) — Bulk Powder Supplier

I3C · CAS 700-06-1

A dietary indole commercially available from Designed Nutritional since 1992. I3C supports healthy estrogen metabolism, normal liver function, and hormone balance.* Sourced from India, warehoused and tested in the USA. Available in bulk powder for supplement brands and formulators worldwide. Min. 99% HPLC purity. Full COA provided with every order.

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CAS Number
700-06-1
Chemical Formula
C₉H₉NO
Molecular Mass
147.18 g/mol
Purity (HPLC)
Min. 99%
Country of Origin
India
Regulatory Status
DSHEA Compliant
Ordering Information
Indole-3-Carbinol (I3C) — Bulk Powder
FormPowder
Minimum Order1 kg
Shelf Life2 years
StorageNo direct sunlight or heat
Small ordersCardboard box + bag
25 kg ordersFiber drum + plastic bag
Warehoused & testedUSA
PricingRequest a quote

COA provided with every order · SDS available on request

Full Technical Specifications

Certificate of Analysis — Specification Sheet

Physical & Chemical Properties
Product Number8038
AppearanceWhite to off-white powder
Melting Point97.0–100.0° C
Loss on DryingNMT 1%
Identification (FTIR)Conforms to reference spectra
Assay (HPLC Purity)Min. 99%
Country of OriginIndia
Warehoused & TestedUSA
Shelf Life2 years
StorageNo direct sunlight or heat
Heavy Metals Testing
Arsenic< 1 ppm
Cadmium< 1 ppm
Mercury< 1 ppm
Lead< 1 ppm
Microbiological Profile
Standard Plate Count< 10,000 cfu/g
Coliforms< 10 cfu/g
E. ColiNegative
SalmonellaNegative
Staph Coag (+)< 10 cfu/g
Yeast & Mold< 100 cfu/g
Formulation Benefits

Why formulators choose I3C

Indole-3-Carbinol is one of the most widely referenced dietary indoles in nutritional science. Since 1992, Designed Nutritional has supplied I3C to supplement brands and formulators building products across hormone balance, women's wellness, liver support, and antioxidant categories. Our I3C is sourced from India and independently warehoused and tested in the USA.

I3C is naturally formed in cruciferous vegetables when cell walls are broken. In the digestive tract, I3C converts to Diindolylmethane (DIM) and other indole derivatives, supporting a broader range of normal hormone metabolism activity than DIM alone. [Ref. 7]
Suggested Dosage Range
200 – 400 mg/day
Adults. Children may take up to ½ adult dosage.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Hormone Balance*

I3C supports healthy estrogen metabolism and promotes normal hormonal balance. Published studies have examined its role in estrogen metabolite ratios, including conversion toward 2-Hydroxyestrone. Widely sourced for hormone balance formulations in women's and men's wellness lines.

Ref. [2] Michnovicz & Bradlow, 1991
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Liver Function Support*

I3C supports normal liver function and healthy metabolic processing. Research has examined its role in liver enzyme activity and the body's natural detoxification pathways. Commonly sourced for liver support and wellness product formulations.

Ref. [1] McDanell et al., 1987
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Antioxidant Activity*

I3C supports normal antioxidant activity and healthy cellular function. Converts to multiple beneficial indole metabolites in the digestive tract, providing broader dietary indole activity than DIM alone. Degradation products are considered beneficial.

Ref. [7] Zeligs, 1998
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Women's Wellness*

I3C supports healthy hormone balance in women, including normal estrogen metabolism associated with cycle and menopause transitions. A widely used ingredient in women's wellness formulations. Two U.S. patents reference I3C compounds in these applications.

U.S. Patent 6,613,792 — Ellenberger et al., 2003
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Specialty Wellness Applications*

I3C supports normal immune and metabolic function. Referenced in published research and U.S. patent filings examining specialty wellness applications. These patents have expired but demonstrate the depth of research behind this ingredient.

U.S. Patent 5,895,787 — Arffmann et al., 1999
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USA Warehoused & Tested

Sourced from India and independently warehoused and tested in the USA. Full HPLC, heavy metals, and microbiological testing performed before release. Certificate of Analysis provided with every order. SDS available on request.

Product Specification — Designed Nutritional No. 8038
Packaging & Ordering

Available packaging options

01

Small Orders

Suitable for sampling, small-batch production, and R&D formulation work. Securely packaged to maintain product integrity during shipping.

Cardboard box with inner bag · MOQ 1 kg
02

Bulk Orders — 25 kg

For production-scale orders. Packed in industrial-grade blue fiber drums with inner plastic liner bags for protection during transit and storage.

Blue fiber drum + plastic bag · 25 kg per drum
03

Custom Quantities

Need a specific quantity or custom packaging? Contact us and we will work with you to meet your production and logistics requirements.

Contact us for custom orders →
U.S. Patents

The following U.S. patents reference 1H-indole-3-methanol (I3C) compounds. These patents have expired. They are listed here as a record of the published research and development history associated with this ingredient.

U.S. Patent 5,895,787
Treatment of Fibromyalgia and Related Disorders
Arffmann et al. — April 20, 1999
A patent describing a method using 1H-indole-3-methanol compounds in relation to fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. This patent has expired.
U.S. Patent 6,613,792
Treatment of Premenstrual Syndrome and Menopause
Ellenberger et al. — September 2, 2003
A patent describing a method using 1H-indole-3-methanol compounds (I3C or ascorbigen) in relation to premenstrual syndrome and menopausal symptoms. This patent has expired.
Synonyms & Alternate Names
  • Indole-3-Carbinol
  • 1H-Indole-3-methanol
  • 3-Hydroxymethylindole
  • 3-Indole methanol
  • I3C
Classification & Regulatory
ClassificationDietary Indole
Regulatory StatusDSHEA Compliant
Facility RegistrationFDA Registered
GMP Standard21 CFR Part 117
Country of OriginIndia
Warehoused & TestedUSA
NoteAll commercial sources are synthetic
Scientific References

Published Research

[1]McDanell, R., et al., 1987. Food and Chemical Toxicology 25: 363–368.
[2]Michnovicz, J.J.; Bradlow, H.L. 1991. Nutrition and Cancer 16: 59–66. Also: Michnovicz, J.J.; Bradlow, H.L. 1990. Journal of the National Cancer Institute 82: 947–949.
[3]Andrus, G.M., Arffman, K., 1999. United States Patent 5,895,787, April 20.
[4]Michnovicz, J.J.; Bradlow, H.L., 1993. Food Phytochemicals I: Fruits and Vegetables 282–293.
[5]Bell, M.C., et al., 2000. Gynecologic Oncology 78: 123–129.
[6]Newfield, L., et al., 1993. Anticancer Research 13: 337–342.
[7]Zeligs, M.A., 1998. Journal of Medicinal Food, 1:2, 67–82.
[8]Loub, W.E.; Wattenberg, L.W.; Davis, D.W., 1975. Journal of the National Cancer Institute 54: 985–988.
[9]Michnovicz, J.J.; Bradlow, H.L., 1989. Proceedings of the Royal Society of Edinburgh 12: 1571–1574.
Stability Note
I3C is stable when protected from direct sunlight and heat. When exposed to light, I3C may darken and eventually become resinous. The degradation products are considered beneficial and are the same compounds formed naturally in the stomach upon ingestion of cruciferous vegetables.
Caution
Amounts in excess of recommended dosages may cause diarrhea.
Note: While dietary indoles occur naturally in cruciferous vegetables, they exist in extremely low quantities. All commercial sources of I3C are synthetic.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References cited are published third-party research provided for informational purposes only.