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Hormone Balance · Proprietary Blend · Product No. 8000

Brox-25™ — Standardized Dietary Indole Blend

Broccoli-based · 25% Minimum Total Dietary Indoles
25%
Minimum Total Dietary Indoles Including DIM, Indole-3-Carbinol (I3C) & Ascorbigen

The only broccoli powder product standardized to a minimum 25% dietary indole content. Brox-25™ is a proprietary blend manufactured in the USA by Designed Nutritional Products since 1992, combining Ascorbigen, Diindolylmethane (DIM), and Indole-3-Carbinol (I3C) in a single bulk powder ingredient. Supports healthy hormone metabolism and normal estrogen balance.* COA provided with every order.

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Product Type
Proprietary Blend
CAS Number
Not applicable — blend
Total Dietary Indoles
25% minimum
Manufactured
USA since 1992
Ingredients sourced
USA & internationally
Regulatory Status
DSHEA Compliant
Ordering Information
Brox-25™ — Bulk Powder
FormOlive to tan powder
Minimum Order5 kg
Shelf Life2 years
StorageAmbient, protect from light
PackagingCardboard box + 2 plastic bags
ManufacturedUSA
PricingRequest a quote

COA provided with every order · SDS available on request

Full Technical Specifications

Certificate of Analysis — Specification Sheet

Physical Properties
Product Number8000
AppearanceOlive to tan free-flowing powder
AromaStrong broccoli and indole smell
TasteCharacteristic of broccoli and indoles
Total Dietary Indole Content25% minimum
Moisture5.5% maximum
Bulk DensityNLT 0.45 g/mL
Particle Size100% through 40 US Standard Sieve
Shelf Life2 years
StorageAmbient, protect from light
ManufacturedUSA
Microbiological Profile
Standard Plate Count< 10,000 cfu/g
Coliforms< 10 cfu/g
E. ColiNegative
SalmonellaNegative
Staph Coag (+)< 10 cfu/g
Yeast & Mold< 1,000 cfu/g
Formulation Benefits

Why formulators choose Brox-25™

Brox-25™ is the only broccoli powder ingredient standardized to a minimum 25% dietary indole content. Manufactured in the USA by Designed Nutritional Products since 1992, it delivers a consistent, measured concentration of three key dietary indoles — Ascorbigen, DIM, and I3C — in a single bulk powder. Ideal for brands seeking a comprehensive dietary indole ingredient without sourcing each compound separately.

In cruciferous vegetables such as broccoli, cauliflower, cabbage, and Brussels sprouts, dietary indoles are produced when cell walls are broken through chopping, chewing, or juicing. These compounds exist in extremely low quantities in their natural form — a few capsules of Brox-25™ delivers the same dietary indole content as several pounds of cruciferous vegetables. [Ref. 10, 11]
Suggested Dosage Range
400 – 1,600 mg/day
Flexible dosage range depending on formulation target. Consult your formulation specialist for application-specific guidance.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Hormone Balance*

Brox-25™ supports healthy hormone metabolism, including normal estrogen balance toward 2-Hydroxyestrone. The combination of DIM, I3C, and Ascorbigen provides comprehensive dietary indole activity for hormone balance formulations in a single ingredient.

Ref. [2] Michnovicz & Bradlow, 1991 · Ref. [3] Michnovicz & Bradlow, 1990
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Liver Function Support*

Dietary indoles support the liver's normal metabolic processes, including healthy processing of hormones and metabolic by-products. Brox-25™ delivers a standardized concentration of multiple dietary indoles for liver support formulations.

Ref. [1] McDanell et al., 1987
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Standardized 25% Minimum Indole Content

The only commercially available broccoli powder standardized to a guaranteed minimum 25% total dietary indole content. Provides consistent, measurable dietary indole delivery in every batch — unlike unstandardized broccoli powders where indole content varies.

Product Specification — Designed Nutritional No. 8000
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Three Dietary Indoles in One Ingredient

Combines Ascorbigen (the most stable dietary indole), DIM (the most studied dietary indole), and I3C (the broadest spectrum dietary indole) in a single bulk powder. Simplifies formulation and sourcing for brands wanting comprehensive dietary indole coverage.

Ref. [10] Zeligs, 1998 · Ref. [11] Loub et al., 1975
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Women's Wellness*

Dietary indoles support healthy hormone balance in women, including normal estrogen metabolism associated with cycle and menopause transitions. Brox-25™ is widely used in women's wellness product lines requiring a complete dietary indole ingredient.

Ref. [4] Michnovicz & Bradlow, 1993 · Ref. [7] Bell et al., 2000
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USA Manufactured Since 1992

Proprietary blend manufactured in the USA by Designed Nutritional Products since 1992. Ingredients sourced from the USA and internationally. Full traceability. COA provided with every order. CFR 117 compliant facility.

Product Specification — Designed Nutritional No. 8000
Packaging & Ordering

Available packaging options

01

Standard Orders

Packaged in cardboard boxes with two inner plastic bags for product protection. Suitable for production runs and formulation work at any scale.

Cardboard box + 2 plastic bags · MOQ 5 kg
02

Bulk Orders

For large-scale production orders. Contact us for bulk pricing and packaging options. We work with you to meet your production and logistics requirements.

Contact us for bulk quantities →
03

Custom Quantities

Need a specific quantity for your formulation run? Contact us directly and we will accommodate your requirements with appropriate packaging and documentation.

Contact us for custom orders →
Product Classification & Regulatory
ClassificationProprietary Dietary Indole Blend
CAS NumberNot applicable — blend
Regulatory StatusDSHEA Compliant
Facility RegistrationFDA Registered
GMP Standard21 CFR Part 117
ManufacturedUSA since 1992
Ingredients sourcedUSA & internationally
Stability & Storage
Light Sensitivity
Most dietary indoles are light sensitive. Store protected from direct light. Degradation products of dietary indoles are considered beneficial and are the same as those formed naturally in the stomach upon ingestion.
Temperature
Ambient storage. Some dietary indoles are heat sensitive. Protect from excessive heat. No refrigeration required.
Shelf Life
2 years from date of manufacture when stored under recommended conditions.
Appearance Change
Natural color variation (olive to tan) is characteristic of this product and does not indicate degradation.
Scientific References

Published Research

[1]McDanell, R. et al. 1987. Food and Chemical Toxicology 25: 363–368.
[2]Michnovicz, J.J.; Bradlow, H.L. 1991. Nutrition and Cancer 16: 59–66.
[3]Michnovicz, J.J.; Bradlow, H.L. 1990. Journal of the National Cancer Institute 82: 947–949.
[4]Michnovicz, J.J.; Bradlow, H.L. 1993. Food Phytochemicals I: Fruits and Vegetables 282–293.
[5]Sepkovic, D. et al. 1994. Steroids 59: 318–323.
[6]Ge, X.; Yannai, S.; Rennert, G.; Gruener, N.; Gares, F.A. 1996. Biochemical and Biophysical Research Communications 28: 153–165.
[7]Bell, M.C. et al. 2000. Gynecologic Oncology 78: 123–129.
[8]Newfield, L. et al. 1993. Anticancer Research 13: 337–342.
[9]Michnovicz, J.J.; Bradlow, H.L. 1989. Proceedings of the Royal Society of Edinburgh 12: 1571–1574.
[10]Zeligs, M.A. 1998. Journal of Medicinal Food 1:2, 67–82.
[11]Loub, W.E.; Wattenberg, L.W.; Davis, D.W. 1975. Journal of the National Cancer Institute 54: 985–988.
[12]Andrus, G.M.; Arffman, K. 1999. United States Patent 5,895,787, April 20.
Caution
Amounts in excess of recommended dosages may cause diarrhea.
Note: While dietary indoles occur naturally in cruciferous vegetables, they exist in extremely low quantities. All commercial sources used in Brox-25™ are synthetic.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References cited are published third-party research provided for informational purposes only.